Regulatory Polymorphisms in Human DBH Affect Peripheral Gene Expression and Sympathetic Activity
نویسندگان
چکیده
منابع مشابه
Regulatory polymorphisms in human DBH affect peripheral gene expression and sympathetic activity.
RATIONALE Dopamine β-hydroxylase (DBH) catalyzes the conversion of dopamine to norepinephrine in the central nervous system and peripherally. DBH variants are associated with large changes in circulating DBH and implicated in multiple disorders; yet causal relationships and tissue-specific effects remain unresolved. OBJECTIVE To characterize regulatory variants in DBH, effect on mRNA expressi...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2014
ISSN: 0009-7330,1524-4571
DOI: 10.1161/circresaha.116.304398